Open Targets Platform REST API

Access api docs as served by Redoc. Mocked via Mockzilla.

Interactive API docs using swagger-ui

Search for the closest term to autocomplete in the search box.

Fire the search method for multiple strings

Get disease objects.

Get disease objects. Available as a Mockzilla mock endpoint.

Get drug objects.

Get ECO objects.

Returns an enrichment analysis for a list of targets passed in the body

Get search-result objects. Enables search bar functionality.

Get relation objects. Mockzilla mock: no signup, no API key.

Get relation objects starting from diseases.

Get relation objects starting from diseases.

Get target objects. Used for the target profile page.

Get gene-expression objects.

Get gene-expression objects. Served by the Mockzilla mock runtime.

Get target objects.

Once we integrate all evidence connecting a target to a specific disease, we compute an association score by the means of an harmonic sum. This association score provides an indication of how strong the evidence behind each connection is and can be used to rank genes in order of likelihood as drug targets. The association ID is constructed by using the Ensembl ID of the gene and the EFO ID for the disease (e.g. ENSG00000073756-EFO_0003767). The method returns an association object, which contains the data and summary on each evidence type included in the calculation of the score, as well as the score itself.

More complex queries for associations scores and objects can be done using this method, which allows to sort in different order, restrict to a specific class of diseases or targets, as well as filtering results by score and associated pathways.

Complex queries and filters for association objects can also be submitted using a JSON object and the equivalent POST method.

We call evidence a unit of data that support a connection between a target and a disease. The Open Targets Platform integrates multiple types of evidence including genetic associations, somatic mutations, RNA expression and target-disease associations mined from the literature. This method allows you to retrieve a single evidence item or a list of pieces of evidence by using their targetvalidation.org ID. Evidence IDs are unique within each data release (e.g. 8ed3d7568a8c6cac9c95cfb869bac762 for release 1.2). You can obtain a list of evidence and their IDs from other API calls such as /public/evidence/filter. Please note that a specific evidence ID may change between data releases. We can not guarantee that a specific evidence ID will refer to the same piece of evidence connecting a target and its diseases. Mocked via Mockzilla.

This is the POST version of /public/evidence. It allows to query for a list of evidence strings encoded in a json object to be passed in the body.

The filter method allows to retrieve the specific data that supports a connection between targets and diseases. Filters can be used to restrict the results by source and type of data, or limit results to targets which are part of a particular pathway. Minimum and maximum scores can be specified as well as the type of evidence linking target and disease. Note that multiple genes and diseases can be specified in the same request.

POST version of /public/evidence/filter. Filters can be specified as part of a json object in the body, simplifying the submission of queries.

This method allows you to look for gene or diseases of interest using a free text search, replicating the functionality of the search box on our homepage. It should be used to identify the best match for a disease or target of interest, rather than gathering a specific set of evidence.

Returns the metrics about associations and evidences, divided by datasource, genes and so on. Available as a Mockzilla mock endpoint.

Check if the API is up

Returns the number of associations and evidences, divided by datasource.

Returns the list of therapeutic areas for the current data release

Returns current API version.

Get swagger.yaml specs for the API. Mockzilla mock: no signup, no API key.